This page lists all main quests in Vampire: The Masquerade – Bloodlines.
- Wherefore Art Thou, Mercurio? – The fledgling is tasked with finding LaCroix's agent, Mercurio.
- Surf's Up – Retrieve the waylaid Astrolite from drug dealers in the beach house.
- Explosive Beginning – Persuade Therese Voerman to cease the feud between herself and Bertram Tung.
- The Ghost Haunts at Midnight – Retrieve an item from the Ocean House hotel for Therese.
- Slashterpiece – Destroy the paintings inside the Gallery Noir for Jeanette Voerman.
- Bad Blood – The fledgling is sent to reassure Jeanette that Therese does not mean to harm her.
- Sibling Rivalry – Jeanette and Therese, at each other's throats, must be persuaded to stand down.
- Elizabethan Rendezvous – The fledgling is tasked with investigating the Elizabeth Dane, and acquiring information about the Ankaran Sarcophagus.
- Calling Dr. Grout – The Malkavian primogen, Alistair Grout, has been remiss in contacting the Prince. LaCroix wants the fledgling to investigate.
- Patron of the Ancient Arts – Retrieve the Ankaran Sarcophagus from the Museum of Natural History.
- The Epic of the Ankaran Sarcophagus – The fledgling jumps through hoops while trying to recover the Ankaran Sarcophagus.
- Dead Ex – Recover a partial snuff film from a courier who has backed out of the deal.
- Snuff Is Enough – The other half of the snuff film is located inside Death Mask Productions' offices.
- Going the Way of Kings – The fledgling's first introduction to a Tzimisce.
- I Spy Barabus – Gary Golden won't scratch the fledgling's back until they've scratched his, by finding one of his Nosferatu agents, Barabus.
- Kikinapped – Wong Ho won't help until the fledgling rescues his daughter, who has been abducted by the Tong.
- Original Gangster – With new clues concerning Barabus, the fledgling heads to Zhao's Imports for help from Wong Ho's "friend", Zhao.
- Dragon's Tail – Inquire about Barabus in the nightclub Glaze.
- Come Into My Parlor – Time to visit the mysterious Mandarin.
- Italian Dinner – Infiltrate the Giovanni Stronghold to obtain the long-sought Ankaran Sarcophagus.
- Society for the Preservation of Professors – A rescue mission is carried out for Dr. Ingvar Johansen, the only authority on the Ankaran Sarcophagus' origin and design.
- Hell at the Hallowbrook Hotel – The Sabbat launch an attack on Venture Tower.
- The Enemy of My Enemy – Find both Nines and a werewolf in Griffith Park's hilltop observatory.
- Out for Blood – LaCroix has issued a Blood Hunt on the fledgling.
- Ming Must Die! – Travel to Chinatown's Golden Temple to deal with Ming Xiao once and for all.
- Royal Flush – Travel to Downtown's Venture Tower to deal with Sebastian LaCroix once and for all.