Lilith met Caine who wandered the Land of Nod as a Kindred. He was scared and unhappy. She tended him and over the course of a few years, she taught him how to use exceptional powers that Caine used to develop the Disciplines.
However, Caine abandoned Lilith and went to Ubar. It is unknown what happened to Lilith afterwards.
Lilith is a god figure for the Bahari, a Kindred cult.