|English voice:||Greg Ellis|
|Partner(s):|| Bertram Tung (regnant)|
I don't know how much I should tell you, but – oh man, damn! – it would be awesome to talk to someone else "on the inside", know what I mean?
―Knox to the fledgling
Personable, overzealous and upbeat, Knox is introduced to the fledgling early in-game when he bumps into them in front of the Santa Monica clinic. Not much is known about Knox's past, other than the encounter that led to him becoming Tung's ghoul, and that he was previously a bounty hunter working for Arthur Kilpatrick.
He somewhat affectionately refers to Tung as the "nasty dude." Knox is extremely happy with his new status as a ghoul, taking the time to explain all the benefits he has gained if asked.
By speaking with Knox, the fledgling can obtain valuable information about ghouls in general, as well as a quest that helps to eventually direct them to Tung, allowing advancement in the main quest line.
Knox is described by Tung as being "able to track like a bloodhound". Coming across as initially motor-mouthed and unsuspecting, it is insinuated that he is much cleverer than let on, going so far as to trick the fledgling if their Inspection is not high enough.
Knox is identifiable by his enthusiastic manner of speaking. He will often punctuate dialogue with exclamations such as "aw, man!" or "hey girl/pal, what's up?"
As a ghoul, Knox has superior strength, agility and a longer lifespan than normal humans, for as long as he's fed Tung's blood. He is also an expert tracker, which is why Tung chose him to be his ghoul.
- When talking to Tung, it can be revealed that most of what Knox said to the fledgling during their first meeting were actually pre-made lines Tung had fed him. This also proves that Knox is far sharper than he appears.
- Knox Harrington shares his name with a character from the Big Lebowski, though this character's personality matches Vandal Cleaver. It's not known if this was intentional.