Personable, overzealous and upbeat, Knox is introduced to the player early in-game, via bumping into him in front of the Santa Monica clinic or inside the Asylum. By speaking with Knox, you obtain valuable information about ghouls as well as a quest that helps to eventually direct you to the Nosferatu, Bertram Tung, allowing you to advance further along in-game.Knox is desribed by his master, Bertram Tung, as being "able to track like a bloodhound". Coming across as initially motor mouthed and unsuspecting, it is insinuated that he is much cleverer than let on, going so far as to trick the player if their Inspection is not high enough.
Knox is indentifiable by his enthusiastic manner of speaking. He will often punctuate dialogue with exclamations such as "Awe, man!" or "Hey girl/guy, what's up?" He shares the golden eye color that is trademark of many ghouls and sports a jacket with a cartoonish vampire emblem. He refers to Bertram Tung as the "nasty dude", although this does not stop him from expounding on the benefits of being a ghoul.
Not much is known about Knox's past other than the encounter that led to his status as Bertram Tung's ghoul and his previous occupation as bounty hunter employed by Arthur Kilpatrick.