'The future of the Vampire: The Masquerade - Bloodlines 2 franchise will rely on the implementation of a “seven-to-ten year cycle,” according to Paradox Interactive’s CEO. In an interview with PCGamesN at PDXCon this weekend, Fred Wester said the company were considering ongoing possibilities for the franchise.

Wester says “we are experimenting with a couple of the White Wolf brands right now,” but are aware that a new franchise can’t be immediately started from scratch ("if you’re going to build a big franchise you need to think in a seven-to-ten year cycle”) and that if the Vampire IP was to receive that kind of attention, “we need to know what the next ten years are going to look like.”

A new Vampire game does seem to be something relatively high on Paradox’s list - Wester acknowledges that a second Vampire game “is an obvious choice” - but it’s not something they can begin yet - “it needs to feel right, it needs to be the right team [...] for the game.” '

(From article here)

Thought this was interesting, however, it's very similar to what Paradox spoke about at last year's PDXCON. They generally said the same thing as above. But still, as long as it keeps being talked about and brought up, things look at least a little hopeful for a Bloodlines sequel.